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New Natural Product from Botryosphaeria australis, an Endophyte from Mangrove Avicennia marinavvvv

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Chemical investigation of the endophytic fungus Botryosphaeria australis isolated from Avicennia marina originally from Hainan Province, P.R. China, yielded a new compound botryosphaenin (1), from the class of napthoquinone, together with 5 known compounds, botryosterpene (2) and 5-hydroxy-2,7-dimethoxynaphthalene 1,4-dione (3) and its derivatives, 6- ethyl-5-hydroxy-2,7-dimethoxynaphthalene-1,4-dione (4), O-methylaspmenone (5), O-methylasparvenone (6) and 5-(carboxymethyl)-7-hydroxy-1,4a-dimethyl-6-methylene decahydron aphthalene-1-carboxylic acid (7). Their structures were determined on the basis of spectroscopic methods including 1D ( 1 H, 13 C, and DEPT) and 2D (COSY, HMQC, HMBC, and ROESY) NMR experiments and by mass spectroscopic measurements The new compounds, 1 showed activity against the bacterial pathogens Staphylococcus aureus, several Streptococcus species and Bacillus subtilis, but also against the eukaryotic cell lines THP-1 (human leukemia monocyte) and BALB/3T3 (mouse embryonic fibroblast).

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Availability

B1801798

Koleksi Digital

Archivelago Indonesia Marine Library - Perpustakaan Kementerian Kelautan dan Perikanan

Available

Detail Information

Series Title

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Call Number

Koleksi Digital

Publisher

2013 : KKP-Badan Penelitian dan Pengembangan Kelautan dan Perikanan., Jakarta

Collation

139-145 hlm.

Language

English

ISBN/ISSN

2089-5690

Classification

NONE

Content Type

-

Media Type

-

Carrier Type

-

Edition

8 (3), 2013

Subject(s)

mangrove
Avicennia Marina
Local Content
Publikasi Internal
antibiotik

Specific Detail Info

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Statement of Responsibility

Squalen Bulletin of Marine & Fisheries Postharvest & Biotechnology

Other version/related

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