Archivelago Indonesia Marine Library

Perpustakaan Kementerian Kelautan dan Perikanan Republik Indonesia

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CYTOTOXIC SATURATED FATTY ACIDS FROM THE INDONESIAN SEA CUCUMBER Holothuria sp

Hedi Indra Januar - Personal Name; Ekowati Chasanah - Personal Name; Muhamad Nursid - Personal Name;

Sea cucumbers are one of Indonesia’s marine organism with the potential to be developed as possible herbal medicines. In a preliminary study of cytotoxic activity of ethanol extracts of 14 Indonesian sea cucumber species, the most active extract came from the Holothuria sp. The current research aimed to identify the major cytotoxic component in the sea cucumber Holothuria sp., that yielded the most active extract. The samples were collected from South Lampung beach. Isolation of the cytotoxic component was done employing liquid flash and preparative reversed phase (C18) chromatography. Cytotoxicity evaluation of fractions collected during the chromatography was conducted using the MCF-7 tumor cell line. Elucidation of the structure of most active isolate was done by NMR (Nuclear Magnetic Resonance) spectroscopy and GC-FID (Gas-Chromatography-Flame Ionisation Detector) analysis. The results of these analyses showed the most active compound to be stearic acid; IC 50 towards MCF-7 cells 10.32 ppm.


Availability
B1707529Koleksi DigitalArchivelago Indonesia Marine Library - Perpustakaan Kementerian Kelautan dan PerikananAvailable
Detail Information
Series Title
-
Call Number
Koleksi Digital
Publisher
Jakarta : Squalen Bulletin of Marine & Fisheries Postharvest & Biotechnology., 2014
Collation
-
Language
English
ISBN/ISSN
2089-5690
Classification
NONE
Content Type
-
Media Type
-
Carrier Type
-
Edition
-
Subject(s)
Jurnal
Local Content
Publikasi Internal
Cytotoxicity
Holothuria sp.
MCF-7
Stearic acid
Specific Detail Info
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Statement of Responsibility
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Archivelago Indonesia Marine Library yang berasal dari gabungan kata ‘archive’ dan ‘archipelago’ yang memiliki makna tempat yang paling sesuai dan lengkap untuk menyimpan informasi mengenai kelautan dan perikanan Indonesia, merupakan perpustakaan khusus di bawah Sekretariat Jenderal Kementerian Kelautan dan Perikanan, dengan koleksi khusus di bidang kelautan dan perikanan.

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